Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Nortriptyline is dosed at 1–2 mg/kg PO q12h in dogs, per Verified against Veterinary Psychopharmacology (Crowell-Davis), 2nd Ed, p.261 (2026-08-01).. Nortriptyline is used in dogs for Separation anxiety / neuropathic pain. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Nortriptyline in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Pamelor
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | 2-4 weeks for behavioral effect | Separation anxiety / neuropathic pain | Weak | Verified against Veterinary Psychopharmacology (Crowell-Davis), 2nd Ed, p.261 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Active metabolite of amitriptyline. Inhibits norepinephrine reuptake preferentially over serotonin. Anticholinergic, antihistaminic, and alpha-adrenergic blocking properties.
Cardiac toxicity risk — monitor ECG in susceptible species. Anticholinergic effects: dry mouth, urinary retention, constipation. Do not combine with MAOIs.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Nortriptyline dose range in dogs, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Nortriptyline in dogs: PO.
Cited course lengths for Nortriptyline in dogs include: 2-4 weeks for behavioral effect. Duration depends on the indication — match it to the specific dose rule in the table above.
Nortriptyline is indicated in dogs for: Separation anxiety / neuropathic pain.
These are general warnings for Nortriptyline across species; consult the dog dosing table above for species-specific guidance. Cardiac toxicity risk — monitor ECG in susceptible species. Anticholinergic effects: dry mouth, urinary retention, constipation. Do not combine with MAOIs.
Why a species-specific page? Nortriptyline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.