Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Paclitaxel is used in dog for Mammary carcinoma / various solid tumors, Osteosarcoma adjuvant (investigational). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Paclitaxel in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Taxol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 132–170 mg/kg | 132-170mg/m2 IV over 2-3 hours q21 days | Premedicate with dexamethasone, diphenhydramine, cimetidine | Mammary carcinoma / various solid tumors | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| IV | 132–170 mg/kg | 132-170mg/m2 IV over 3h q21 days x 4-6 cycles | Monitor CBC, liver, renal function per cycle | Osteosarcoma adjuvant (investigational) | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Promotes microtubule assembly and stabilizes formed microtubules, preventing depolymerization. Arrests cells in G2/M phase by disrupting mitotic spindle function.
Anaphylaxis from Cremophor EL vehicle — premedicate with corticosteroids and antihistamines. Myelosuppression and peripheral neuropathy. Requires slow IV infusion.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Paclitaxel pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.