Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Paroxetine is dosed at 0.5–2 mg/kg PO q24h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1016 (2026-08-01). — Plumb's 10th ed (held) printed p.989, Paroxetine monograph spanning p.988-989; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Paroxetine is used in dogs for Anxiety disorders, compulsive behaviors. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Paroxetine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Paxil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q24h | Weeks to months | Anxiety disorders, compulsive behaviors | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1016 (2026-08-01). — Plumb's 10th ed (held) printed p.989, Paroxetine monograph spanning p.988-989; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1–2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.322 | 1-2 mg/kg p.o. q24h |
| 0.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.640 | • 0.5 mg/kg/day PO. For some compulsive disorders, increase the dose to 1 mg/kg |
| 1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.640 | • 0.5 mg/kg/day PO. For some compulsive disorders, increase the dose to 1 mg/kg |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selective serotonin reuptake inhibitor. Also has mild anticholinergic activity contributing to anxiolytic effects.
Used for anxiety disorders, aggression, and compulsive behaviors. 4-6 weeks for full effect. Serotonin syndrome risk. GI upset initially. Do not combine with MAO inhibitors.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Paroxetine dose range in dogs, with cited source references: PO 0.5–2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Paroxetine in dogs: PO.
Cited course lengths for Paroxetine in dogs include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Paroxetine is indicated in dogs for: Anxiety disorders, compulsive behaviors.
These are general warnings for Paroxetine across species; consult the dog dosing table above for species-specific guidance. Used for anxiety disorders, aggression, and compulsive behaviors. 4-6 weeks for full effect. Serotonin syndrome risk. GI upset initially. Do not combine with MAO inhibitors.
Why a species-specific page? Paroxetine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.