Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Temozolomide is used in dog for Brain tumors (glioma), Melanoma (investigational). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Temozolomide in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Temodar
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 60–80 mg/kg | 60-80mg/m2 PO q24h x 5 days per 28-day cycle | Repeat cycles if tolerated; MRI response assessment | Brain tumors (glioma) | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| PO | 60–80 mg/kg | 60-80mg/m2 PO q24h x 5 days q28 days | Monitor CBC and tumor response per cycle | Melanoma (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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Prodrug that spontaneously converts to MTIC at physiologic pH. Methylates DNA at O6-guanine and N7-guanine, causing cytotoxic DNA damage. Crosses blood-brain barrier.
Good CNS penetration — used for brain tumors. Myelosuppression (thrombocytopenia, neutropenia). Take on empty stomach. Monitor CBC. Used investigationally in dogs for glioma.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Temozolomide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.