ExoticRx · exoticrx.com/drugs/tobramycin-systemic
US brand names:Nebcin
Tobramycin Systemic is dosed at 5–10 mg/kg IM q12h in great horned owls, per Samour, Avian Medicine, 3rd Ed. (raptor formulary appendix), p.655. Row as printed binds this dose to raptors on its own line: "Tobramycin Nebcin Injection Raptors IM 5-10 mg/kg bid for 5-7 d Least nephrotoxic of all current". Located by line-level extraction and then read on the page; the species binding is the row's own species column, not text proximity.. Verify against current literature before clinical use.
Binds 30S ribosomal subunit causing misreading of mRNA. Bactericidal. Particularly effective against Pseudomonas aeruginosa.
Nephrotoxic and ototoxic. Therapeutic drug monitoring essential. Avoid concurrent nephrotoxins. Ensure adequate hydration.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Great Horned Owl drugsAll Harris Hawk drugsAll Peregrine Falcon drugsAll Red-tailed Hawk drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 6 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | IV | 2–3 mg/kg | q8h or 5-8 mg/kg q24h | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1247-1248 (corpus PDF p.1274-1275), Tobramycin, Systemic monograph, Dosages — DOGS & CATS [LOCATOR CORRECTED 2026-08-12 — the clause previously here named the Tobramycin Ophthalmic monograph]; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | IV | 2–4 mg/kg | q8h or 6-10 mg/kg q24h | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1247-1248 (corpus PDF p.1274-1275), Tobramycin, Systemic monograph, Dosages — DOGS & CATS [LOCATOR CORRECTED 2026-08-12 — the clause previously here named the Tobramycin Ophthalmic monograph]; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.1247-1248, Tobramycin, Systemic monograph [LOCATOR CORRECTED 2026-08-12 — the clause previously here named the Polymyxin B, Systemic monograph, a different antibiotic]; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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