Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Topotecan is used in dog for Lymphoma / solid tumors (investigational). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Topotecan in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Hycamtin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.75–1 mg/kg | IV over 30 min q24h x 5d, q21d cycles | Monitor CBC — nadir day 7-10 | Lymphoma / solid tumors (investigational) | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Semi-synthetic camptothecin analogue that inhibits topoisomerase I by stabilizing the enzyme-DNA complex, preventing DNA religation and causing lethal double-strand breaks.
Severe myelosuppression is dose-limiting. Monitor CBC closely. Dose-reduce in renal impairment. Used investigationally for lymphoma and solid tumors in dogs.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Topotecan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.