Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Trabectedin is used in dog for Soft tissue sarcoma (investigational). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Trabectedin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Yondelis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.15–0.3 mg/kg | 0.15-0.3mg/m2 IV over 3-24h q21 days | Requires central line; monitor liver enzymes | Soft tissue sarcoma (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds to minor groove of DNA, bending the helix toward the major groove. Interferes with transcription-coupled nucleotide excision repair and modulates tumor microenvironment.
Hepatotoxicity — monitor liver enzymes. Myelosuppression. Requires central venous access. Very limited veterinary data — investigational for soft tissue sarcomas.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Trabectedin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.