What is Voriconazole used for?

Voriconazole is indicated for: Aspergillosis (nasal and disseminated), Fungal infections.

Which species have cited Voriconazole dosing data?

Voriconazole dosing in the ExoticRx formulary covers 2 species: Dog (Domestic), Russian Tortoise.

Is Voriconazole a controlled substance?

Voriconazole is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Voriconazole

US brand names:Vfend

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Voriconazole is dosed at 10 mg/kg PO not specified in russian tortoises, per Merck Veterinary Manual. Antimicrobial Drugs Used in Reptiles (dosing table). Rahway (NJ): Merck & Co.; accessed 2026. URL: https://www.merckvetmanual.com/multimedia/table/antimicrobial-drugs-used-in-reptiles. Verify against current literature before clinical use.

Drug Class

Antifungal

Routes

POIV

Indications

Aspergillosis (nasal and disseminated)Fungal infections

Mechanism of Action

Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase), blocking ergosterol synthesis. Broader spectrum than fluconazole including Aspergillus.

Side effects & warnings

Drug of choice for aspergillosis. Hepatotoxic — monitor liver enzymes. Many CYP-mediated drug interactions. Visual disturbances in humans. Non-linear pharmacokinetics in some species.

Species with Voriconazole dosing data (2 dose rules)

Dog (Domestic)Russian Tortoise

Species references:All Dog (Domestic) drugs All Russian Tortoise drugs

Evidence levels across 2 dose rules

Moderate×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· Graupmann-Kuzma A, Valentine BA, Shubitz LF, Dial SM, Watrous B, Tornquist SJ. Coccidioidomycosis in dogs and cats: A review. J Am Anim Hosp Assoc. 2008;44:226-235. doi:10.5326/0440226 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1343 (2026-08-01).
· Merck Veterinary Manual. Antimicrobial Drugs Used in Reptiles (dosing table). Rahway (NJ): Merck & Co.; accessed 2026. URL: https://www.merckvetmanual.com/multimedia/table/antimicrobial-drugs-used-in-reptiles

Sample dosing (1 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	3–4 mg/kg	q12h	Moderate	Graupmann-Kuzma A, Valentine BA, Shubitz LF, Dial SM, Watrous B, Tornquist SJ. Coccidioidomycosis in dogs and cats: A review. J Am Anim Hosp Assoc. 2008;44:226-235. doi:10.5326/0440226 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1343 (2026-08-01).

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