Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Yohimbine is dosed at 0.11 mg/kg IV once; administer slowly IV in dogs, per Plumb's Veterinary Drug Handbook 9th ed, Yohimbine, Dosages > DOGS, printed p.1325 (corpus 1352); Yobine label, NADA# 140-866; corroborated by Papich, Saunders Handbook of Veterinary Drugs 5th ed, printed p.854 (corpus 882). Yohimbine is used in dogs for Xylazine reversal. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Yohimbine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Yobine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.11 mg/kg | once; administer slowly IV | Single dose | Xylazine reversal | Moderate | Plumb's Veterinary Drug Handbook 9th ed, Yohimbine, Dosages > DOGS, printed p.1325 (corpus 1352); Yobine label, NADA# 140-866; corroborated by Papich, Saunders Handbook of Veterinary Drugs 5th ed, printed p.854 (corpus 882) |
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Alpha-2 adrenergic antagonist reversing sedation from xylazine and other alpha-2 agonists. Less selective than atipamezole.
Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Yohimbine dose range in dogs, with cited source references: IV 0.11 mg/kg once; administer slowly IV. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Yohimbine in dogs: IV.
Cited course lengths for Yohimbine in dogs include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Yohimbine is indicated in dogs for: Xylazine reversal.
These are general warnings for Yohimbine across species; consult the dog dosing table above for species-specific guidance. Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Why a species-specific page? Yohimbine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.