Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Yohimbine is dosed at 0.11 mg/kg IV once; administer slowly IV in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Yohimbine, Dosages > DOGS, printed p.1325 (corpus 1352); Yobine label, NADA# 140-866; corroborated by Papich, Saunders Handbook of Veterinary Drugs 5th ed, printed p.854 (corpus 882) — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Yohimbine is used in dogs for Xylazine reversal. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Yohimbine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Yobine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.11 mg/kg |
| once; administer slowly IV |
| Single dose |
| Xylazine reversal |
| Moderate |
| Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Yohimbine, Dosages > DOGS, printed p.1325 (corpus 1352); Yobine label, NADA# 140-866; corroborated by Papich, Saunders Handbook of Veterinary Drugs 5th ed, printed p.854 (corpus 882) — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
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Alpha-2 adrenergic antagonist reversing sedation from xylazine and other alpha-2 agonists. Less selective than atipamezole.
Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Yohimbine dose range in dogs, with cited source references: IV 0.11 mg/kg once; administer slowly IV. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Yohimbine in dogs: IV.
Cited course lengths for Yohimbine in dogs include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Yohimbine is indicated in dogs for: Xylazine reversal.
These are general warnings for Yohimbine across species; consult the dog dosing table above for species-specific guidance. Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Why a species-specific page? Yohimbine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.