Yohimbine for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Yohimbine is used in dog for Xylazine reversal. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Yohimbine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Yobine
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.14 mg/kg | IV slowly | Single dose | Xylazine reversal | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Alpha-2 adrenergic antagonist reversing sedation from xylazine and other alpha-2 agonists. Less selective than atipamezole.
Side effects & warnings
Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antidote drugs with dog dosing
Why a species-specific page? Yohimbine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.