Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sunitinib is dosed at 2–3.5 mg/kg PO PO q24h on 4 weeks on / 2 weeks off schedule in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed. Sunitinib is used in dogs for Mast cell tumors / hemangiosarcoma (investigational), Renal carcinoma / GIST (investigational). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Sunitinib in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sutent
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–3.5 mg/kg | PO q24h on 4 weeks on / 2 weeks off schedule | Monitor CBC, thyroid, cardiac function per cycle | Mast cell tumors / hemangiosarcoma (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| PO | 2–3 mg/kg | PO q24h, 4 weeks on / 2 weeks off | Monitor response with imaging per cycle | Renal carcinoma / GIST (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits multiple receptor tyrosine kinases: VEGFR-1/2/3, PDGFR-alpha/beta, c-KIT, FLT-3, CSF-1R, and RET. Anti-angiogenic and direct anti-tumor activity.
Cardiotoxicity risk — monitor cardiac function. Hypothyroidism, hypertension, GI toxicity. Yellow skin discoloration. Limited veterinary data.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sunitinib dose ranges in dogs, with cited source references: PO 2–3.5 mg/kg PO q24h on 4 weeks on / 2 weeks off schedule; PO 2–3 mg/kg PO q24h, 4 weeks on / 2 weeks off. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sunitinib in dogs: PO.
Cited course lengths for Sunitinib in dogs include: Monitor CBC, thyroid, cardiac function per cycle; Monitor response with imaging per cycle. Duration depends on the indication — match it to the specific dose rule in the table above.
Sunitinib is indicated in dogs for: Mast cell tumors / hemangiosarcoma (investigational), Renal carcinoma / GIST (investigational).
These are general warnings for Sunitinib across species; consult the dog dosing table above for species-specific guidance. Cardiotoxicity risk — monitor cardiac function. Hypothyroidism, hypertension, GI toxicity. Yellow skin discoloration. Limited veterinary data.
Why a species-specific page? Sunitinib pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.