Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Vitamin K1 is dosed at 2.5–5 mg/kg PO q24h (total daily dose) in dogs, per Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, printed p.638 (corpus PDF p.666) - Phytonadione, Small Animal Dosage, Dogs and Cats: 'Treatment of long-acting rodenticides: 2.5-5 mg/kg/day for 3-4 weeks IM, SQ, or PO.' Same figure in Riviere & Papich, Veterinary Pharmacology & Therapeutics (vpt) printed p.638: 'For treatment of long-acting rodenticides administer 2.5-5 mg/kg/day for 3-4 weeks IM, SC, or PO.' And in the exotic ECC text (eecc PDF p.374): 'Vitamin K1 2.5-5 mg/kg IM q24h x 4-6 days (warfarin), x 21-28 days (brodifacoum).'. Vitamin K1 is used in dogs for Anticoagulant rodenticide poisoning. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Vitamin K1 in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Mephyton, AquaMEPHYTON, Veta-K1
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–5 mg/kg | q24h (total daily dose) | 4-6 weeks for long-acting rodenticides | Anticoagulant rodenticide poisoning | Strong | Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, printed p.638 (corpus PDF p.666) - Phytonadione, Small Animal Dosage, Dogs and Cats: 'Treatment of long-acting rodenticides: 2.5-5 mg/kg/day for 3-4 weeks IM, SQ, or PO.' Same figure in Riviere & Papich, Veterinary Pharmacology & Therapeutics (vpt) printed p.638: 'For treatment of long-acting rodenticides administer 2.5-5 mg/kg/day for 3-4 weeks IM, SC, or PO.' And in the exotic ECC text (eecc PDF p.374): 'Vitamin K1 2.5-5 mg/kg IM q24h x 4-6 days (warfarin), x 21-28 days (brodifacoum).' |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Essential cofactor for hepatic carboxylation of clotting factors II, VII, IX, X. Reverses vitamin K-dependent coagulopathy from anticoagulant rodenticides.
Give PO with fatty food (fat-soluble). SC preferred over IM (hematoma risk) or IV (anaphylaxis risk). Long-acting rodenticides (brodifacoum) require 4-6 weeks treatment. Monitor PT.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Vitamin K1 dose range in dogs, with cited source references: PO 2.5–5 mg/kg q24h (total daily dose). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Vitamin K1 in dogs: PO.
Cited course lengths for Vitamin K1 in dogs include: 4-6 weeks for long-acting rodenticides. Duration depends on the indication — match it to the specific dose rule in the table above.
Vitamin K1 is indicated in dogs for: Anticoagulant rodenticide poisoning.
These are general warnings for Vitamin K1 across species; consult the dog dosing table above for species-specific guidance. Give PO with fatty food (fat-soluble). SC preferred over IM (hematoma risk) or IV (anaphylaxis risk). Long-acting rodenticides (brodifacoum) require 4-6 weeks treatment. Monitor PT.
Why a species-specific page? Vitamin K1 pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.