Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Vitamin K1 is dosed at 2.5–5 mg/kg PO q24h (total daily dose) in dogs, per Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, printed p.638 (corpus PDF p.666) - Phytonadione, Small Animal Dosage, Dogs and Cats: 'Treatment of long-acting rodenticides: 2.5-5 mg/kg/day for 3-4 weeks IM, SQ, or PO.' Same figure in Riviere & Papich, Veterinary Pharmacology & Therapeutics (vpt) printed p.638: 'For treatment of long-acting rodenticides administer 2.5-5 mg/kg/day for 3-4 weeks IM, SC, or PO.' And in the exotic ECC text (eecc PDF p.374): 'Vitamin K1 2.5-5 mg/kg IM q24h x 4-6 days (warfarin), x 21-28 days (brodifacoum).' — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, https://openlibrary.org/isbn/9781118855829. Vitamin K1 is used in dogs for Anticoagulant rodenticide poisoning. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Vitamin K1 in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Mephyton, AquaMEPHYTON, Veta-K1
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–5 mg/kg |
| q24h (total daily dose) |
| 4-6 weeks for long-acting rodenticides |
| Anticoagulant rodenticide poisoning |
| Weak |
| Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, printed p.638 (corpus PDF p.666) - Phytonadione, Small Animal Dosage, Dogs and Cats: 'Treatment of long-acting rodenticides: 2.5-5 mg/kg/day for 3-4 weeks IM, SQ, or PO.' Same figure in Riviere & Papich, Veterinary Pharmacology & Therapeutics (vpt) printed p.638: 'For treatment of long-acting rodenticides administer 2.5-5 mg/kg/day for 3-4 weeks IM, SC, or PO.' And in the exotic ECC text (eecc PDF p.374): 'Vitamin K1 2.5-5 mg/kg IM q24h x 4-6 days (warfarin), x 21-28 days (brodifacoum).' — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, https://openlibrary.org/isbn/9781118855829 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2.5 | SC | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.450 | in toxicity or vitamin K1 deficiency: initially 2.5 mg/kg s.c. in several sites, then 1-2.5 mg/kg in divided doses p.o. q8-12h for 5-7 d |
| 1–2.5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.450 | deficiency: initially 2.5 mg/kg s.c. in several sites, then 1-2.5 mg/kg in divided doses p.o. q8-12h for 5-7 days. • Known 2nd generation coumarin (bro |
| 5 | SC | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.450 | n 2nd generation coumarin (brodifacoum) toxicity: initially 5 mg/kg s.c. in several sites, then 2.5 mg/kg p.o. q12h for 3 weeks, then re-evaluate |
| 2.5 | PO |
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Essential cofactor for hepatic carboxylation of clotting factors II, VII, IX, X. Reverses vitamin K-dependent coagulopathy from anticoagulant rodenticides.
Give PO with fatty food (fat-soluble). SC preferred over IM (hematoma risk) or IV (anaphylaxis risk). Long-acting rodenticides (brodifacoum) require 4-6 weeks treatment. Monitor PT.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Vitamin K1 dose range in dogs, with cited source references: PO 2.5–5 mg/kg q24h (total daily dose). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Vitamin K1 in dogs: PO.
Cited course lengths for Vitamin K1 in dogs include: 4-6 weeks for long-acting rodenticides. Duration depends on the indication — match it to the specific dose rule in the table above.
Vitamin K1 is indicated in dogs for: Anticoagulant rodenticide poisoning.
These are general warnings for Vitamin K1 across species; consult the dog dosing table above for species-specific guidance. Give PO with fatty food (fat-soluble). SC preferred over IM (hematoma risk) or IV (anaphylaxis risk). Long-acting rodenticides (brodifacoum) require 4-6 weeks treatment. Monitor PT.
Why a species-specific page? Vitamin K1 pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| xicity: initially 2.5-5 mg/kg s.c. over several sites. Then 2.5 mg/kg p.o. divided q8-12h for 3-4 weeks. Re-evaluate coagulation status 2 days after stopping t |
| 2.5–5 | SC | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.450 | (diphacinone) or unknown anticoagulant toxicity: initially 2.5-5 mg/kg s.c. over several sites. Then 2.5 mg/kg p.o. divided q8-12h for 3-4 weeks. Re- |
| 0.5–1 | SC | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.450 | times as above. • Liver disease (pre-biopsy): 0.5-1.0 mg/kg s.c. q12h. After 1-2 days re-evaluate coagulation time and if normal proceed w |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.